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Generally speaking, antidepressants will not interact with the effectiveness of your birth control. The combination of the two could potentially cause changes to your mood, though. Antidepressants can affect your hormone levels, and hormonal birth control is comprised of synthetic hormones, so there may be some interaction between medicines. If you feel like your mood has changed significantly since taking this combination of medicine, it may be time to chat with your doctor about alternative options. These medications—such as felbamate, lamotrigine, phenobarbital, and primidone— can interfere with the effectiveness of your birth control. At Simple Health, we ask you to share your medical history and take it into consideration when selecting a birth control method for you.