Medically reviewed by Timothy J. PDF Download. Figure 4. Here are 7 effects of overeating. Antidepressant-induced weight gain is tied to appetite changes. Is increased antidepressant exposure a contributory factor to the obesity pandemic? Lyons WE, et al. Each sample was injected 10 times and the enrichment was calculated as the mean of the last 5 injections to exclude any memory confounding effect deriving from previous injections. We found that FLX treatment of adult mice reduces weight gain both in normal conditions and upon obesity which correlate with higher energy expenditure, increased response to acute leptin and higher hypothalamic BDNF.
Noninvasive treatments like environmental stimulation are able to increase response to leptin and induce BDNF expression in the brain. Emerging evidences point to the antidepressant selective serotonin reuptake inhibitor Fluoxetine FLX as a drug with effects similar to environmental stimulation. FLX is known to impact on body weight, with mechanisms yet to be elucidated. Wild type obese mice treated with FLX showed reduced weight gain, increased energy output, and differently from untreated obese mice, a preserved acute response to leptin in terms of activation of the intracellular leptin transducer STAT3. In conclusion, FLX impacts on energy balance and induces leptin sensitivity and an intact TrkB function is required for these effects to take place. The hormone leptin, secreted by the white adipose tissue WAT, plays a key role in the complex interplay between peripheral organs and the brain to regulate body weight 1, by informing the brain about the status of long-term energy stores, in order to repress food intake and promote energy expenditure 2. The former is activated by leptin and induces an anorectic response 6, whereas the latter, inhibited by leptin, stimulates feeding 7. The above depicted scenario is how the system should work to regulate energy balance and prevent excessive weight accumulation.
Unfortunately, it didn’t quite work out that way. If you’ve noticed yourself overeating, you may wonder how it affects your body. Noninvasive treatments like environmental stimulation are able to increase response to leptin and induce BDNF expression in the brain. Two-thirds of patients with major depression present with weight loss, and gaining weight can be associated with successful treatment. Author and Disclosure Information Thomas L. Schwartz, MD Zsuzsa S.