Tag Archives: dolutegravir

People with NNRTI resistance have poorer responses to dolutegravir, South African study finds

People with HIV who already have resistance to a non-nucleoside reverse transcriptase inhibitor (NNRTI) when they start first-line antiretroviral treatment containing the integrase inhibitor dolutegravir were less likely to achieve viral suppression, a large clinical trial in South Africa has reported. NNRTI resistance has not been shown to affect responses to dolutegravir-based treatment previously. The… Read More »

ADVANCE study shows high frequency of major weight gain in women receiving dolutegravir with TAF

Metabolic syndrome – including obesity – developed significantly more frequently in people who received dolutegravir, tenofovir alafenamide (TAF) and emtricitabine compared to other regimens in the South African ADVANCE study, Michelle Moorhouse reported on Thursday at the 17th European AIDS Conference in Basel, Switzerland. Furthermore, updated follow-up from the study showed that close to 60%… Read More »