Tag Archives: responses

People with NNRTI resistance have poorer responses to dolutegravir, South African study finds

People with HIV who already have resistance to a non-nucleoside reverse transcriptase inhibitor (NNRTI) when they start first-line antiretroviral treatment containing the integrase inhibitor dolutegravir were less likely to achieve viral suppression, a large clinical trial in South Africa has reported. NNRTI resistance has not been shown to affect responses to dolutegravir-based treatment previously. The… Read More »

What and how much we eat might change our internal clocks and hormone responses

For the first time, a study shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours. The research conducted in mice found that the time-of-day dependent metabolic cycle is altered by high caloric diet. Since glucocorticoids… Read More »