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In patients being treated for depression, which antidepressants have a low risk of sexual side effects? Bupropion Wellbutrin, nefazodone Serzone, amitriptyline Elavil, and moclobemide Manerix, a reversible inhibitor of monoamine oxidase type A not available in the United States have been shown to cause less sexual dysfunction than selective serotonin reuptake inhibitors SSRIs. Information from references 1 through 4. The incidence of sexual side effects between different antidepressants in adults with depressive or anxiety disorders has been reported by 25 RCTs, most of which were included in two recent descriptive systematic reviews. The number needed to harm NNH, that is, the number of patients who have to take the drug for one patient to experience sexual dysfunction, ranged from two to 17, depending on the type of dysfunction. There were no other consistent differences between classes of antidepressants. One trial reported less sexual dysfunction resulting from amitriptyline than from sertraline NNH: seven, but numerous trials have not shown differences between clomipramine Anafranil and other SSRIs. Bupropion appears to be the best antidepressant for use in patients who are concerned about drug-related sexual dysfunction.
For many, taking antidepressants means experiencing some form of sexual dysfunction. Experts are still researching the sexual side effects caused by antidepressants to figure out why they happen and how to prevent them. There may be some antidepressants that cause fewer sexual side effects, and there are also promising ways to manage or prevent these effects. Taking antidepressant drugs can cause a wide range of side effects. Everything from gut issues to anxiety have been reported by people who take antidepressants. Until recently, the sexual side effects caused by antidepressants were not often discussed with patients before prescribing the medications. The symptoms of sexual dysfunction caused by taking antidepressants were highlighted in a recent study posted to Drug, Healthcare and Patient Safety.