NCBI Bookshelf. Pegah Akbari ; Arshia Khorasani-Zadeh. By doing so, thiazide diuretics promote natriuresis and diuresis. Three thiazide diuretics are commonly used: hydrochlorothiazide HCTZ, chlorthalidone, and indapamide. Thiazide diuretics are also indicated for use although not FDA-approved for nephrolithiasis, osteoporosis, and diabetes insipidus. The method of activation of thiazide diuretics is to cause a change in Na concentration distal to the DCT. Subsequently, ionic channels and pumps work to balance disrupted Na levels. This secondary change to balance Na levels produces many adverse effects. The MOA and its effects on the nephron will be more thoroughly discussed below and will be referred to in the adverse effects section.
A diuretic is a medicine which increases the amount of water that you pass out from your kidneys. A diuretic causes an increase in urine, called a diuresis. So, they are sometimes called ‘water tablets’. There are different types of diuretics which work in different ways and thiazide diuretics are one type of diuretic. Thiazide diuretics are a common treatment for high blood pressure hypertension.
Thiazide diuretics are a type of diuretic a drug that increases urine flow. Thiazides decrease sodium reabsorption which increases fluid loss in urine, which in turn decreases extracellular fluid and plasma volume. This reduces cardiac output how hard the heart has to work to pump blood around the body and lowers blood pressure. Thiazides also work in other ways to lower blood pressure. Thiazides also cause potassium loss while retaining calcium.